Researchers successfully tackle a multiscale Osteoarthritic knee challenge – Modelathon 2020


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1st EPSRC MultiSim Interdisciplinary Workshop on Multiscale Modelling


29th March 2019, ICOSS, University of Sheffield

Event Report


Insigneo Institute for in silico Medicine


The Insigneo Institute for in silico Medicine has been created to achieve the scientific ambition behind the Virtual Physiological Human (VPH), producing a transformational impact on healthcare.  Find out more


An introduction to our research


Focused on the human musculoskeletal system but designed as a generic platform to address other engineering challenges that involve multi-scale modelling, unobservable states and variables and uncertainty. Find out more


Background

MultiSim is a £6.7 million EPSRC Frontier Engineering Award project based  at the University of Sheffield's Insigneo Institute for in silico Medicine. This five year multidisciplinary project started on 1st September 2013, and extended until 1st September 2021 with Progression Grant funding, involving academics from the Faculty of Engineering and the Faculty of Medicine, Dentistry and Healthcare. M...

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Publications: find out more about our research

Heterogeneous strain distribution in the subchondral bone of osteoarthritic femoral heads measured with digital volume correlation

Heterogeneous strain distribution in the subchondral bone of osteoarthritic femoral heads measured with digital volume correlation

Osteoarthritis affects the properties of the joints, changing its shape and mechanical response, and inducing pain to the patient. We still do not know how the complex structure of osteoarthritic bone deforms ...
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Development of subject specific finite element models of the mouse knee joint for preclinical applications

Development of subject specific finite element models of the mouse knee joint for preclinical applications

Osteoarthritis affects the properties of the joints, changing its shape and mechanical response, and inducing pain to the patient. Mouse models are commonly used to identify the effect of mechanical instabilit...
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PTH(1–34) treatment and/or mechanical loading have different osteogenic effects on the trabecular and cortical bone in the ovariectomized C57BL/6 mouse

PTH(1–34) treatment and/or mechanical loading have different osteogenic effects on the trabecular and cortical bone in the ovariectomized C57BL/6 mouse

Figure showing increased apposition of bone (in red) when combining treatment (ML+PTH and ML+PTHalt), particularly in the midshaft (top row) and posterior and laterally where strains are highest under compress...
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Our goals and aspirations

Dr Enrico Dall'Ara, MultiSim Work Package Leader
“The goal of Multisim is to combine experimental, imaging and computational approaches to improve current preclinical and clinical assessment of musculoskeletal diseases and to optimise treatments for patients”
Professor Claudia Mazzà , Director of MultiSim
“MultiSim wants to bring the most advanced engineering techniques to the service of the patient by working on clinically-ready solutions for the personalisation of healthcare.”