Researchers successfully tackle a multiscale Osteoarthritic knee challenge – Modelathon 2020


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1st EPSRC MultiSim Interdisciplinary Workshop on Multiscale Modelling


29th March 2019, ICOSS, University of Sheffield

Event Report


Insigneo Institute for in silico Medicine


The Insigneo Institute for in silico Medicine has been created to achieve the scientific ambition behind the Virtual Physiological Human (VPH), producing a transformational impact on healthcare.  Find out more


An introduction to our research


Focused on the human musculoskeletal system but designed as a generic platform to address other engineering challenges that involve multi-scale modelling, unobservable states and variables and uncertainty. Find out more


Background

MultiSim is a £6.7 million EPSRC Frontier Engineering Award project based  at the University of Sheffield's Insigneo Institute for in silico Medicine. This five year multidisciplinary project started on 1st September 2013, and extended until 1st September 2021 with Progression Grant funding, involving academics from the Faculty of Engineering and the Faculty of Medicine, Dentistry and Healthcare. M...

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Publications: find out more about our research

Non-invasive prediction of the mouse tibia mechanical properties from microCT images

Non-invasive prediction of the mouse tibia mechanical properties from microCT images

Overview of Methods Used: Osteoporosis is one of the most common chronic diseases of the musculoskeletal system. New bone treatments require in vivo testing before clinical translation, and the mouse tibia...
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Analysis of mechanotransduction dynamics during combined mechanical stimulation and modulation of the extracellular-regulated kinase cascade uncovers hidden information within the signalling noise

Analysis of mechanotransduction dynamics during combined mechanical stimulation and modulation of the extracellular-regulated kinase cascade uncovers hidden information within the signalling noise

Hybrid Mechanical and Agent Based Model Framework Osteoporosis is a bone disease that leads to bone fragility and an increased risk of their fracture. By 2025, osteoporosis will cost the NHS over £2.2 billi...
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Femoral neck strain prediction during level walking using a combined musculoskeletal and finite element model approach

Femoral neck strain prediction during level walking using a combined musculoskeletal and finite element model approach

Musculoskeletal and finite element models describing forces in femur while walking Coupled musculoskeletal-finite element modelling approaches have emerged in recent years as a novel way to investigate femo...
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Our goals and aspirations

Dr Enrico Dall'Ara, MultiSim Work Package Leader
“The goal of Multisim is to combine experimental, imaging and computational approaches to improve current preclinical and clinical assessment of musculoskeletal diseases and to optimise treatments for patients”
Professor Claudia Mazzà , Director of MultiSim
“MultiSim wants to bring the most advanced engineering techniques to the service of the patient by working on clinically-ready solutions for the personalisation of healthcare.”