Success at our multi-scale modelling competition


Modelathon 2018 received very positive feedback from our participants. Find out more


1st EPSRC MultiSim Interdisciplinary Workshop on Multiscale Modelling


29th March 2019, ICOSS, University of Sheffield

Event Report


Insigneo Institute for in silico Medicine


The Insigneo Institute for in silico Medicine has been created to achieve the scientific ambition behind the Virtual Physiological Human (VPH), producing a transformational impact on healthcare.  Find out more


An introduction to our research


Focused on the human musculoskeletal system but designed as a generic platform to address other engineering challenges that involve multi-scale modelling, unobservable states and variables and uncertainty. Find out more


Background

MultiSim is a £6.7 million EPSRC Frontier Engineering Award project based  at the University of Sheffield's Insigneo Institute for in silico Medicine. This five year multidisciplinary project started on 1st September 2013, and extended until 1st September 2021 with Progression Grant funding, involving academics from the Faculty of Engineering and the Faculty of Medicine, Dentistry and Healthcare. M...

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Publications: find out more about our research

Biomechanical assessment of vertebrae with lytic metastases with subject-specific finite element models

Biomechanical assessment of vertebrae with lytic metastases with subject-specific finite element models

The assessment of risk of vertebral fracture in patients with lytic metastases is challenging, due to the complexity in understanding their impact on the vertebral strength. Currently surgeons have to dec...
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Linking Joint Impairment and Gait Biomechanics in Patients with Juvenile Idiopathic Arthritis

Linking Joint Impairment and Gait Biomechanics in Patients with Juvenile Idiopathic Arthritis

Radar plot visualisation of the joint contact force and joint power parameters normalised using robust z score. * = bilateral group significantly different from mono-lateral; † = bilateral group significantly di...
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Effect of cell sample size in atomic force microscopy nanoindentation

Effect of cell sample size in atomic force microscopy nanoindentation

Graphical Abstract, showing cells, atomic force microscopy and the effect of sample size on the coefficient of variance of the Young's modulus of the cells Cells in the human body can be classified in many...
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Our goals and aspirations

Dr Enrico Dall'Ara, MultiSim Work Package Leader
“The goal of Multisim is to combine experimental, imaging and computational approaches to improve current preclinical and clinical assessment of musculoskeletal diseases and to optimise treatments for patients”
Professor Claudia Mazzà , Director of MultiSim
“MultiSim wants to bring the most advanced engineering techniques to the service of the patient by working on clinically-ready solutions for the personalisation of healthcare.”