Effect of cell sample size in atomic force microscopy nanoindentation

Graphical Abstract, showing cells, atomic force microscopy and the effect of sample size on the coefficient of variance of the Young's modulus of the cells Cells in the human body can be classified in many different ways. One of these is looking at their mechanical properties, and therefore at how stiff or soft they are. This characteristic has been shown to correlate to d...
View

Pre-operative Prediction of Soft Tissue Balancing in Knee Arthoplasty

The definition of the body joints: ball socket (hip) and hinge (knee and ankle) A 2011 survey made over 18 developed high income countries reported that over 1.3 million total knee replacements are performed every year world-wide.  Since then these number have increased, because of the ageing of the population.  While only a few percent of the patients experience...
View

1st EPSRC MultiSim Interdisciplinary Workshop on Multiscale Modelling

29th March 2019, ICOSS, University of Sheffield Participants networking and comparing approaches and challenges of using multiscale modelling in their disciplines On Friday, 29th March, a bright sunny Spring day in Sheffield, researchers from across disciplines in science and engineering with an interest in multiscale modelling gathered at the ICOSS Conference Centre. Th...
View

Prenatal growth map of the mouse knee joint by means of deformable registration technique

Methodological Pipeline Joint morphogenesis is the process of development of the joint that starts before the birth. It is important to study joint morphogenesis in order to understand how it is related to musculoskeletal diseases and to optimise related interventions. In several cases the interventions are tested on animal models and the mouse pre-natal model is typic...
View

MultiSim2 Awarded

Second phase of funding to expand research into modelling the human musculoskeletal system to tackle a broader range of ageing related and neurodegenerative conditions University of Sheffield research into modelling of human musculoskeletal system to assist the assessment, diagnosis and treatment options for individual patients has received a second phase funding via th...
View

MultiSim Researcher, Aban Shuaib wins a Santander Mobility Award and visits IBEC, Barcelona to develop collaborations

Cellular and Molecular Mechanobiology Laboratory (CMML), Institute for Bioengineering of Catalonia (IBEC), Barcelona MultiSim researcher, Aban Shuaib, wins a Santander Mobility Award to visit Institute for Bioengineering of Catalonia (IBEC), Barcelona to develop collaborations with the Cellular and Molecular Mechanobiology Laboratory (CMML) based there. Santander Mobili...
View

MultiSim Researcher, Aban Shuaib, invited to McGill University, Canada, to present his Agent-Based Modelling (ABM) work

MacDonald Engineering Building, McGill University, Montreal, Canada Aban Shuaib, a MultiSim researcher working on the simulations of bone remodelling using agent based modelling (ABM) was invited to present his work at McGill University (Montreal, Canada). Aban was invited by Professor Luc Mongeau, Chair of the Department of Mechanical Engineering (https://www.mcgill.ca/mec...
View

Former MultiSim Researcher Giuliano Lamberto’s Role in Corin

Giuliano Lamberto joined the Insigneo Institute as a PhD student under the supervision of Professor Claudia Mazzà in the Department of Mechanical Engineering and also worked on the MultiSim project as a Research Associate.  He is now working as an NPI [New Product Introduction] development engineer in the orthopaedic field for Corin, a medical device manufacturer based in ...
View

Journal of Biomechanics Highlights MultiSim Paper

Image-based Kinematic Ankle Model Congratulations to the Erica Montefiori, et al., their paper will be one of the highlighted papers in the forthcoming edition of the Journal of Biomechanics (85C), and appear on the its home page. For a lay summary of the paper see: http://multisim-insigneo.org/image-based-kinematic-ankle-models-for-children-affected-by-juvenile-idiopa...
View

Poroelastic Modeling of Highly Hydrated Collagen Hydrogels: Experimental Results vs. Numerical Simulation with Custom and Commercial Finite Element Solvers

With the non-stop advances in computational methods and tools, researchers have a wide range of possibilities when it comes to choosing the most appropriate software for their work. In the field of biomechanics and biomaterials, one of the most used tools to predict and understand the behaviour of materials and devices is the finite element method, which allows for the ...
View