The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia: A comparison between two mouse strains

A thorough assessment of any prospective animal model of human disease is necessary before the substantial investment of resources into a preclinical study of potential therapies. Oestrogen-deficiency and related bone loss following ovariectomy is a common animal model of osteoporosis. In this study we quantified the effects of ovariectomy on the tibia bone morphometric, densi...
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Finite Element Modelling of the Developing Infant Femur Using Paired CT and MRI Scans

Finite Element models of infant femur (left– 4 months; right– 7 months) Through the MultiSim project in Sheffield, we have pioneered modelling technologies to investigate very young children’s bone using personalised computer models based on CT and MRI scans. This work is the first of its kind to combine information obtained from paired CT/MRI data in order to create deta...
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Biomechanical assessment of vertebrae with lytic metastases with subject-specific finite element models

The assessment of risk of vertebral fracture in patients with lytic metastases is challenging, due to the complexity in understanding their impact on the vertebral strength. Currently surgeons have to decide whether to fix the spine with implants or not, just based on their experience and on qualitative scoring systems such as the Spinal Instability Neoplastic Score (SINS...
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Linking Joint Impairment and Gait Biomechanics in Patients with Juvenile Idiopathic Arthritis

Radar plot visualisation of the joint contact force and joint power parameters normalised using robust z score
Radar plot visualisation of the joint contact force and joint power parameters normalised using robust z score. * = bilateral group significantly different from mono-lateral; † = bilateral group significantly different from control. This study, carried out as part of the MD-PAEDIGREE project, combines medical resonance images (MRI) and motion capture analysis to produce perso...
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Insigneo Team Visit Diamond Light Source

Beamtime on the Diamond Manchester Imaging Beamline (I13-2) was awarded to Dr Enrico Dall’Ara and Dr Bryant Roberts for proposal No: MG21628 “Assessing the individual and combined effects of parathyroid hormone (1-34) and mechanical loading on the micro- and nano-structural properties of murine cortical bone”. This study was partially funded by EPSRC MultiSim Grant: EP/K03877X...
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