Angels of the North

Women's Movement 100: Angels of the North by Freddie Garland MultiSim's Director, Claudia Mazzà has been collaborating with dancer and choreographer Freddie Garland, Tenfoot Dance Company, in her continuing project 'Women's Movement 100: Angels of the North' to create a filmed performance about women’s suffrage, emancipation and health for Festival of the Mind. Enjoy the r...
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MRI-based anatomical characterisation of lower-limb muscles in older women

Linear regression between muscle volume and anthropometric parameters
Linear regression between muscle volume and anthropometric parameters The ability of muscles to produce force depends, among others, on their anatomical features and it is altered by ageing-associated weakening. This MRI-based study quantified for the first time anatomical asymmetry of lower-limb muscles in older women by characterising muscle volume, length, and physiologi...
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Bone remodelling in the mouse tibia is spatio-temporally modulated by oestrogen deficiency and external mechanical loading: A combined in vivo/in silico study

Graphical Abstract Understanding how bone formation and resorption are affected by several repeated periods of mechanical stimuli is important for developing personalised treatment plans for osteoporosis. In this study, the load-induced bone changes after the first and second week of mechanical loading was quantified for the first time in an animal model of osteoporosis. Co...
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Heterogeneous strain distribution in the subchondral bone of osteoarthritic femoral heads measured with digital volume correlation

Osteoarthritis affects the properties of the joints, changing its shape and mechanical response, and inducing pain to the patient. We still do not know how the complex structure of osteoarthritic bone deforms under load, due to the challenging experimental approaches required to evaluate the internal deformation in bone specimens. The goal of this study was to develop a method...
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Development of subject specific finite element models of the mouse knee joint for preclinical applications

Finite Element Models of the Knee Joint with increasing complexity
Osteoarthritis affects the properties of the joints, changing its shape and mechanical response, and inducing pain to the patient. Mouse models are commonly used to identify the effect of mechanical instability of the joint on its structure and to optimise treatments for reducing the joint degeneration. Computational models can be used to better understand the effect of the de...
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PTH(1–34) treatment and/or mechanical loading have different osteogenic effects on the trabecular and cortical bone in the ovariectomized C57BL/6 mouse

Figure showing increased apposition of bone (in red) when combining treatment (ML+PTH and ML+PTHalt), particularly in the midshaft (top row) and posterior and laterally where strains are highest under compressive load This study quantified the individual and combined longitudinal effects of PTH(1–34) and loading on the bone morphometric and densitometric properties in ovari...
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A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint

Flow diagram illustrating the methods to extract the trabecular bone cortical bone volumes for morphometric analysis. Osteoarthritis affects the properties of the joints, changing its shape and mechanical response, and inducing pain to the patient. However, little is known about how these properties are related to the function of the joint, which is fundamental to optimis...
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Researchers successfully tackle a multiscale Osteoarthritic knee challenge – Modelathon 2020

Modelathon Participants and Supporters The MultiSim, OATech+ Modelathon 2020 took place 13 – 16 January 2020 at the Diamond Building, Sheffield and aimed to provide an opportunity to discuss, network, and practise multi-scale research modelling skills through a hackathon competition with industry software and hands-on support from modelling experts. Modelathon 2020 was atte...
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Effect of size and location of simulated lytic lesions on the structural properties of human vertebral bodies, a micro-finite element study

Graphical Abstract The study of the risk of fractures in cancer patients with spine metastases is important to improve the quality of life of patients. Currently, the risk of fracture in these patients is evaluated using clinical scoring systems that account for information about the location of the cancer, the pain, and other qualitative factors. While this approac...
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