Preclinical assessment of bone health

Dr. Enrico Dall'Ara  presented a seminar on Preclinical assessment of bone health with longitudinal imaging and finite element modelling at INSERM institute, Lyon, France. His session was hosted by Prof Philippe Clezardin and Dr Helene Follet. Dr Dall'Ara joined the University of Sheffield in 2013 in the Department of Mechanical Engineering. His research focuses on a better ...
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Success at tackling multi-scale problems: Modelathon 2017

The MultiSim Modelathon 2017 took place 11 – 14 September 2017 at the Diamond Building, Sheffield and aimed to provide an opportunity to discuss, network, and practise multi-scale research modelling skills through a hackathon competition with industry software and hands-on support from modelling experts. Modelathon 2017 was attended by 26 multi-scale researchers from a number o...
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Modelathon 2018: Using multi-scale modelling for new treatments of osteoarthritic joints.

17-20 September 2018, The Diamond Building, University of Sheffield, Sheffield Day 1 only (Agenda for Days 2-4 is below) Day 2-4   Registration is now  closed  Our four-day EPSRC funded Modelathon* event brings together the very best of theory and practice in the area of multi-scale modelling. After 3 successful events, and in response to last ye...
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Micro Finite Element models of the vertebral body: Validation of local displacement predictions

Computational models can be used to estimate the mechanical properties of bones under certain loading conditions. However, even if they are based on high-resolution micro-computed tomography (microCT) scans which provide information about the bone density and micro architecture, they need to be validated against accurate and well controlled experiments in the laboratory. In ...
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Professor Lacroix’s plenary keynote on multiscale modelling of the musculoskeletal system

Plenary keynote at the International Conference on Computational Bioengineering: Multiscale modelling of the musculoskeletal system Damien Lacroix is a Professor of Biomedical Engineering University of Sheffield's Department of Mechanical Engineering and is the Director of Research at the Insigneo Institute for in silico Medicine. Damien will be presenting at  the Internatio...
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Collaboration with NC3Rs to reduce animal testing

Murine-embryo-stained-for-bone-and-cartilage
University of Sheffield's researchers are trying to find ways to reduce animal testing in preclinical trials by using computer models and medical imaging. One application of this technology, also known as in silico methods, is to study the effect of skeletal diseases such as osteoporosis and its treatments.Using in silico methods, researchers conducted a longitudinal study o...
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Aban Shuaib

Aban’s multi-disciplinary research is at the interface between medicine, engineering and computational modelling. He is a part of the MultiSim project work-package 5, which focuses on modelling molecular and cellular events triggered when a cell is exposed to mechanical stimulation. Cell biology is his main field of interest with intracellular signalling and communication as...
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Journal of Biomechanics: Accuracy of synchrotron based digital volume correlation for bone tissue

MultiSim's Dr Enrico Dall'Ara  talks about his paper on the accuracy of synchrotron-based digital volume correlation for bone tissue. His research was featured on the homepage of the Journal of Biomechanics edition published in July 2017. Understanding bone mechanics at different hierarchical levels is fundamental to improve preclinical and clinical assessments of bone stren...
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Professional development for researchers

Training PDRAs at MultiSim
MultiSim has 12 post-doctoral researchers/research assistants (PDRAs). We interviewed this group to explore how they felt MultiSim has contributed to their professional development so far. The paragraphs below provide an overview of their feedback on the training opportunities we offer. Our interviews found that PDRAs actively seek new training opportunities and are self-aware ...
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