Bone remodelling in the mouse tibia is spatio-temporally modulated by oestrogen deficiency and external mechanical loading: A combined in vivo/in silico study

Graphical Abstract

Understanding how bone formation and resorption are affected by several repeated periods of mechanical stimuli is important for developing personalised treatment plans for osteoporosis. In this study, the load-induced bone changes after the first and second week of mechanical loading was quantified for the first time in an animal model of osteoporosis. Computational modelling (finite element analysis) was used to evaluate the extent bone adaptation is driven by mechanical factors. This combined experimental-computational approach improves our understanding of the drivers for bone adaptation, which can be applied to design better interventions and biomaterials to treat osteoporosis.

Cheong, V. S., Roberts, B. C., Kadirkamanathan, V., Dall’Ara, E. (2020), “Bone remodelling in the mouse tibia is spatio-temporally modulated by oestrogen deficiency and external mechanical loading: a combined in vivo/in silico study”, Acta Biomaterialia, URL: https://doi.org/10.1016/j.actbio.2020.09.011