Variability in strain distribution in the mice tibia loading model: A preliminary study using digital volume correlation

  The study of bone remodeling, how bone tissue changes over time due to the activity of bone cells, is fundamental for the better understanding of musculoskeletal diseases and to design new treatments. Bone adapts to external loading and exercise can be used to stimulate the formation of new tissue in order to strengthen the bones.  Animal studies on small roden...
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Researchers successfully tackle a multiscale Osteoarthritis challenge – Modelathon 2018

The MultiSim, OATech+ Modelathon 2018 took place 17 – 20 September 2017 at the Diamond Building, Sheffield and aimed to provide an opportunity to discuss, network, and practise multi-scale research modelling skills through a hackathon competition with industry software and hands-on support from modelling experts. Modelathon 2018 was attended by 15 multi-scale researchers from a...
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The Kroto Research Inspiration Poster Competition 2018 Winner is … Erica Montefiori, a MultiSim researcher

Congratulations to Erica Montefiori on winning the Kroto Research Inspiration poster competition Erica Montefiori, a Research Assistant on our MultiSim project, has been awarded best poster at the The Kroto Research Inspiration Poster Competition 2018 for her poster ‘Becoming a hip fracture detective!’ Her poster, which is co-authored by Dr Pinaki Bhattacharya, communica...
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Ivan Benemerito

Ivan Benemerito, a PhD student associated with the MultiSim project, has recently successfully defended his PhD thesis. Ivan describes how his experience in MultiSim has prepared him for his new role in CompBioMed. "I got my Bachelor degree in Aerospace Engineering from Sapienza Università di Roma, and my Master degree in Mathematical Engineering for Università di Roma T...
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Zainab Altai joins MultiSim as a researcher in musculoskeletal biomechanics

Zainab Altai Zainab Altai has recently joined the MultiSim project after completing her PhD at the Insigneo for in silico Medicine, under the Supervision of Dr Xinshan Lee, and has written about her time at Insigneo. "I got my MSc degree in Mechanical engineering from Almustansiriyah University in Baghdad. I won a scholarship, fully funded by the HCED in Iraq, t...
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Pinaki Bhattacharya: MultiSim Research Associate becomes Lecturer in Solid Biomechanics in the Insigneo Institute

                          I am excited to join the Department of Mechanical Engineering and the Insigneo Institute for in silico Medicine at the University of Sheffield as a Lecturer in Solid Biomechanics. I will be teaching the module Regulatory Affairs in Medical Device...
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New study improves monitoring of treatments for multiple sclerosis

Pioneering research in Multiple Sclerosis collects patient data under ‘real life’ conditions to improve monitoring of treatments and disease progression Over 100,000 people have MS in the UK with around 5,000 newly diagnosed every year Research could help clinicians monitor condition more accurately for first time and assess effectiveness of treatments In the UK, 75...
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MultiSim’s research on the strength of children’s bones could help in the design of safer car seats

New research from MultiSim's academics based at Insigneo and Sheffield Children's hospitals looks into the strength of children's bones which could help in the design of safer car seats. The first study of its kind into infant bone strength in relation to age and weight using computer simulations The research from University of Sheffield, Sheffield Teaching Hospitals NH...
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Pioneering workshop on the resilience of complex engineering systems hosted at the University of Sheffield

    On 18 January 2018, EPSRC’s MultiSim Frontier Engineering Award and the ENCORE network hosted a joint workshop that explored new ideas on how to use multi-scale modelling in complex engineering systems to improve resilience and function. The workshop was attended by over 50 leading engineers, statisticians, clinicians and early career researchers. As ...
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Fine tuning scan time for improving preclinical assessment of bone tissue

  MultiSim’s researchers are trying to find ways to reduce and refine animal testing in pre-clinical trials by using computer models and medical imaging.  One application of these approaches is to study the effect of skeletal diseases such as osteoporosis and its treatments. At the University of Sheffield, high-resolution scans can be performed on mice to measure...
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