News Archives - MultiSim

MultiSim2 goes ‘Beyond Academia’ with a CLEAR IDEAS Workshop

Posted on November 14, 2019November 15, 2019 by MultiSim

Kamal Birdi, warms participants by looking at chindōgu, weird Japanese inventions On Wednesday, 23rd October, our MultiSim2 project hosted a Clear Ideas workshop: Beyond Academia. The workshop was attended by the MultiSim2 team and Insigneo Associate Members from the IMSB (Integrated Musculo-Skeletal Biomechanics) group explored how to take their research Beyond Acad...

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EPSRC Engineering Research for Grand Challenges

Posted on September 18, 2019September 18, 2019 by MultiSim

MultiSim Stand at EPSRC Engineering Research for Grand Challenges, before the rushVisitors at MultiSim's stand at EPSRC Engineering Research for Grand ChallengeMultiSim Stand at EPSRC Engineering Research for Grand ChallengesMultiSim2 Team at Engineering Research for Grand Challenges Event (Left to Right) Erica Montefiori, Claudia Mazzà and Vee San Cheong Members of the Mul...

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MultiSim2 Launch

Posted on September 16, 2019September 16, 2019 by MultiSim

MultiSim2 Project Team and Scientific Advisory Board (SAB) Left to Right:Dr Joel Mitchelson, Codamotion (SAB),Dr Richard Mead, Neuroscience, University of Sheffield (SAB),Dr Bryant Roberts, Oncology and Metabolism (Researcher),Prof Claudia Mazzà, Mechanical Engineering (Principal Investigator) ,Dr Xinshan Li, Mechanical Engineering (Co-Investigator),Dr Enrico Dall'ara, Oncol...

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Modelathon 2020: Optimisation of interventions for osteoarthritic patients with multi-scale modelling

Posted on August 9, 2019December 4, 2019 by MultiSim

Monday, 13th, 10:00 to Thursday 16th, 13:00 January 2020 The Diamond, University of Sheffield Day 1 Symposium: Experimental and computational approaches to optimise the treatment of osteoarthritis Day 2-4 Challenges: Optimisation of interventions for osteoarthritic patients with multi-scale modelling Agenda coming soon ... Our four-day EPSRC fu...

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The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia: A comparison between two mouse strains

Posted on August 8, 2019August 8, 2019 by MultiSim

A thorough assessment of any prospective animal model of human disease is necessary before the substantial investment of resources into a preclinical study of potential therapies. Oestrogen-deficiency and related bone loss following ovariectomy is a common animal model of osteoporosis. In this study we quantified the effects of ovariectomy on the tibia bone morphometric, densi...

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Finite Element Modelling of the Developing Infant Femur Using Paired CT and MRI Scans

Posted on August 6, 2019August 6, 2019 by MultiSim

Finite Element models of infant femur (left– 4 months; right– 7 months) Through the MultiSim project in Sheffield, we have pioneered modelling technologies to investigate very young children’s bone using personalised computer models based on CT and MRI scans. This work is the first of its kind to combine information obtained from paired CT/MRI data in order to create deta...

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Insigneo Team Visit Diamond Light Source

Posted on May 3, 2019May 3, 2019 by MultiSim

Beamtime on the Diamond Manchester Imaging Beamline (I13-2) was awarded to Dr Enrico Dall’Ara and Dr Bryant Roberts for proposal No: MG21628 “Assessing the individual and combined effects of parathyroid hormone (1-34) and mechanical loading on the micro- and nano-structural properties of murine cortical bone”. This study was partially funded by EPSRC MultiSim Grant: EP/K03877X...

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Effect of cell sample size in atomic force microscopy nanoindentation

Posted on April 18, 2019April 18, 2019 by MultiSim

Graphical Abstract, showing cells, atomic force microscopy and the effect of sample size on the coefficient of variance of the Young's modulus of the cells Cells in the human body can be classified in many different ways. One of these is looking at their mechanical properties, and therefore at how stiff or soft they are. This characteristic has been shown to correlate to d...

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1st EPSRC MultiSim Interdisciplinary Workshop on Multiscale Modelling

Posted on April 2, 2019April 2, 2019 by MultiSim

29th March 2019, ICOSS, University of Sheffield Participants networking and comparing approaches and challenges of using multiscale modelling in their disciplines On Friday, 29th March, a bright sunny Spring day in Sheffield, researchers from across disciplines in science and engineering with an interest in multiscale modelling gathered at the ICOSS Conference Centre. Th...

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Prenatal growth map of the mouse knee joint by means of deformable registration technique

Posted on March 25, 2019April 17, 2019 by MultiSim

Methodological Pipeline Joint morphogenesis is the process of development of the joint that starts before the birth. It is important to study joint morphogenesis in order to understand how it is related to musculoskeletal diseases and to optimise related interventions. In several cases the interventions are tested on animal models and the mouse pre-natal model is typic...

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