My professional development at MultiSim: Mario Giorgi

Mario Giorgi, shares his journey of professional development as a post-doctoral researcher on the MultiSim project based at the University of Sheffield's Insigneo Institute for in silico Medicine.  "I joined Insigneo in July 2015 on the Multisim Frontier Grant, and have now been a part of this amazing group for almost two years. Before joining MultiSim, I knew that this proj...
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Preclinical assessment of bone health

Dr. Enrico Dall'Ara  presented a seminar on Preclinical assessment of bone health with longitudinal imaging and finite element modelling at INSERM institute, Lyon, France. His session was hosted by Prof Philippe Clezardin and Dr Helene Follet. Dr Dall'Ara joined the University of Sheffield in 2013 in the Department of Mechanical Engineering. His research focuses on a better ...
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Success at tackling multi-scale problems: Modelathon 2017

The MultiSim Modelathon 2017 took place 11 – 14 September 2017 at the Diamond Building, Sheffield and aimed to provide an opportunity to discuss, network, and practise multi-scale research modelling skills through a hackathon competition with industry software and hands-on support from modelling experts. Modelathon 2017 was attended by 26 multi-scale researchers from a number o...
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Micro Finite Element models of the vertebral body: Validation of local displacement predictions

Computational models can be used to estimate the mechanical properties of bones under certain loading conditions. However, even if they are based on high-resolution micro-computed tomography (microCT) scans which provide information about the bone density and micro architecture, they need to be validated against accurate and well controlled experiments in the laboratory. In ...
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Professor Lacroix’s plenary keynote on multiscale modelling of the musculoskeletal system

Plenary keynote at the International Conference on Computational Bioengineering: Multiscale modelling of the musculoskeletal system Damien Lacroix is a Professor of Biomedical Engineering University of Sheffield's Department of Mechanical Engineering and is the Director of Research at the Insigneo Institute for in silico Medicine. Damien will be presenting at  the Internatio...
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Programme set to help more under-represented teenagers reach their potential

The Brilliant Club is an award-winning charity that exists to increase the number of pupils from under-represented backgrounds progressing to highly-selective universities. They do this by mobilising the PhD community to share its academic expertise with state schools. Sofia, a PhD student on the MultiSim project at the University of Sheffield’s Insigneo Institute participat...
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Collaboration with NC3Rs to reduce animal testing

Murine-embryo-stained-for-bone-and-cartilage
University of Sheffield's researchers are trying to find ways to reduce animal testing in preclinical trials by using computer models and medical imaging. One application of this technology, also known as in silico methods, is to study the effect of skeletal diseases such as osteoporosis and its treatments.Using in silico methods, researchers conducted a longitudinal study o...
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Journal of Biomechanics: Accuracy of synchrotron based digital volume correlation for bone tissue

MultiSim's Dr Enrico Dall'Ara  talks about his paper on the accuracy of synchrotron-based digital volume correlation for bone tissue. His research was featured on the homepage of the Journal of Biomechanics edition published in July 2017. Understanding bone mechanics at different hierarchical levels is fundamental to improve preclinical and clinical assessments of bone stren...
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Sheffield: Alternatives to Research Requiring Rodents

The Sheffield event was attended by Dr Kasia Makowska, NC3Rs Press and Communications Officer: The event took place in a microbrewery, getting some curious looks from the beer-tasting tours. Dr Enrico Dall’Arra a researcher on the MultiSim project spoke about using a computer model, or a ‘digital mouse’, to better understand the mechanisms behind bone-related diseases. H...
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