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EPSRC Engineering Research for Grand Challenges

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MultiSim Stand at EPSRC Engineering Research for Grand Challenges, before the rushVisitors at MultiSim's stand at EPSRC Engineering Research for Grand ChallengeMultiSim Stand at EPSRC Engineering Research for Grand ChallengesMultiSim2 Team at Engineering Research for Grand Challenges Event (Left to Right) Erica Montefiori, Claudia Mazzà and Vee San Cheong Members of the Mul...
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MultiSim2 Launch

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MultiSim2 Team and SAB
MultiSim2 Project Team and Scientific Advisory Board (SAB) Left to Right:Dr Joel Mitchelson, Codamotion (SAB),Dr Richard Mead, Neuroscience, University of Sheffield (SAB),Dr Bryant Roberts, Oncology and Metabolism (Researcher),Prof Claudia Mazzà, Mechanical Engineering (Principal Investigator) ,Dr Xinshan Li, Mechanical Engineering (Co-Investigator),Dr Enrico Dall'ara, Oncol...
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Modelathon 2020: Optimisation of interventions for osteoarthritic patients with multi-scale modelling

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Monday, 13th, 10:00 to Thursday 16th, 13:00 January 2020 The Diamond, University of Sheffield Day 1 Symposium: Experimental and computational approaches to optimise the treatment of osteoarthritis Speakers confirmed (see below), agenda coming soon ... Day 2-4 Challenges: Optimisation of interventions for osteoarthritic patients with multi-scale modell...
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The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia: A comparison between two mouse strains

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A thorough assessment of any prospective animal model of human disease is necessary before the substantial investment of resources into a preclinical study of potential therapies. Oestrogen-deficiency and related bone loss following ovariectomy is a common animal model of osteoporosis. In this study we quantified the effects of ovariectomy on the tibia bone morphometric, densi...
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Finite Element Modelling of the Developing Infant Femur Using Paired CT and MRI Scans

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Finite Element models of infant femur (left– 4 months; right– 7 months) Through the MultiSim project in Sheffield, we have pioneered modelling technologies to investigate very young children’s bone using personalised computer models based on CT and MRI scans. This work is the first of its kind to combine information obtained from paired CT/MRI data in order to create deta...
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Insigneo Team Visit Diamond Light Source

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Beamtime on the Diamond Manchester Imaging Beamline (I13-2) was awarded to Dr Enrico Dall’Ara and Dr Bryant Roberts for proposal No: MG21628 “Assessing the individual and combined effects of parathyroid hormone (1-34) and mechanical loading on the micro- and nano-structural properties of murine cortical bone”. This study was partially funded by EPSRC MultiSim Grant: EP/K03877X...
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Effect of cell sample size in atomic force microscopy nanoindentation

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Graphical Abstract, showing cells, atomic force microscopy and the effect of sample size on the coefficient of variance of the Young's modulus of the cells Cells in the human body can be classified in many different ways. One of these is looking at their mechanical properties, and therefore at how stiff or soft they are. This characteristic has been shown to correlate to d...
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1st EPSRC MultiSim Interdisciplinary Workshop on Multiscale Modelling

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29th March 2019, ICOSS, University of Sheffield Participants networking and comparing approaches and challenges of using multiscale modelling in their disciplines On Friday, 29th March, a bright sunny Spring day in Sheffield, researchers from across disciplines in science and engineering with an interest in multiscale modelling gathered at the ICOSS Conference Centre. Th...
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Prenatal growth map of the mouse knee joint by means of deformable registration technique

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Methodological Pipeline Joint morphogenesis is the process of development of the joint that starts before the birth. It is important to study joint morphogenesis in order to understand how it is related to musculoskeletal diseases and to optimise related interventions. In several cases the interventions are tested on animal models and the mouse pre-natal model is typic...
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MultiSim2 Awarded

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Second phase of funding to expand research into modelling the human musculoskeletal system to tackle a broader range of ageing related and neurodegenerative conditions University of Sheffield research into modelling of human musculoskeletal system to assist the assessment, diagnosis and treatment options for individual patients has received a second phase funding via th...
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