Collaboration with NC3Rs to reduce animal testing

Murine-embryo-stained-for-bone-and-cartilage
University of Sheffield's researchers are trying to find ways to reduce animal testing in preclinical trials by using computer models and medical imaging. One application of this technology, also known as in silico methods, is to study the effect of skeletal diseases such as osteoporosis and its treatments.Using in silico methods, researchers conducted a longitudinal study o...
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Professional development for researchers

Training PDRAs at MultiSim
MultiSim has 12 post-doctoral researchers/research assistants (PDRAs). We interviewed this group to explore how they felt MultiSim has contributed to their professional development so far. The paragraphs below provide an overview of their feedback on the training opportunities we offer. Our interviews found that PDRAs actively seek new training opportunities and are self-aware ...
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Sheffield: Alternatives to Research Requiring Rodents

The Sheffield event was attended by Dr Kasia Makowska, NC3Rs Press and Communications Officer: The event took place in a microbrewery, getting some curious looks from the beer-tasting tours. Dr Enrico Dall’Arra a researcher on the MultiSim project spoke about using a computer model, or a ‘digital mouse’, to better understand the mechanisms behind bone-related diseases. H...
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A multiscale modelling competition recommended by researchers – Modelathon 2017

Winning team at Modelathon 2016
All of last year's participants felt they gained new skills from our MultiScale Modelling competition 'Modelathon' and would recommend it to a friend*. Find out more.... To register and find out more about this year's event visit our webpage: Modelathon 2017     The challenge explained At the 2016 Modelathon, participants were asked to design ad...
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Our participation at the International & European Society of Biomechanics

We are pleased to announce our participation at the prestigious Congress of the International Society of Biomechanics (ISB)  the largest gathering of experts in the field of biomechanics. It presents a wonderful opportunity for our researchers to receive feedback and have engaging discussions in niche research areas and an opportunity to kick-start potential collaborations....
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Iain Hannah

Where are they now? Iain Hannah obtained an MEng in Mechanical Engineering (with German) from the University of Sheffield and after completing his PhD at Loughborough he joined Insigneo as a Postdoctoral Research Associate on the MultiSim project. He now works as a Simulation Engineer for the Adidas FUTURE Team in Herzogenaurach, Germany. I completed a PhD at Loughbor...
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Experimental validation of DXA-based finite element models for prediction of femoral strength

Osteoporotic fractures are a major clinical problem and current diagnostic tools have an accuracy of only 50%. The standard clinical assessment of Osteoporosis is based on an exam called dual energy X-rays absorptiometry (DXA) with which the local areal bone mineral density is measured at the hip. However, this investigation has been found to be, in some cases, a poor predictor...
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