MultiSim’s research on the strength of children’s bones could help in the design of safer car seats

New research from MultiSim's academics based at Insigneo and Sheffield Children's hospitals looks into the strength of children's bones which could help in the design of safer car seats. The first study of its kind into infant bone strength in relation to age and weight using computer simulations The research from University of Sheffield, Sheffield Teaching Hospitals NH...
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Validation of calcaneus trabecular microstructure measurements by HR-pQCT

In the clinical management of osteoporosis, the most common bone disease that is associated with reduced bone strength and increased risk of broken bones (fractures), it is useful to be able to assess bone strength in individual patients.  Bone strength depends on the amount of bone (bone mass) as well as its structure.  The heel bone is a very accessible site for assessing bon...
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Precision of Digital Volume Correlation Approaches for Strain Analysis in Bone Imaged with Micro-Computed Tomography at Different Dimensional Levels

University of Sheffield's researchers are improving the assessment of deformation in bone tissue using "Digital Volume Correlation" (DVC) approach that is considered a state-of-the-art image-processing technique. This research aims to improve our knowledge about bone fracture mechanism. Particularly focusing on the bone fracture mechanism due to bone and joint diseases su...
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Moving from laboratory to real life conditions: influence on the assessment of variability and stability of gait

Researchers from MultiSim have been involved in a collaborative study about measuring gait analysis outside laboratory conditions. This collaboration was a result of the European Society of Biomechanics 2016 mobility award for young researchers awarded to Paola Tamburini. Gait analysis (i.e. measuring how someone walks) can be a handy tool to assess how well someone walks an...
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A new proxy measurement algorithm with applications to vertical ground reaction forces with wearable sensors

A proxy measurement is commonly used when direct measures of the outcome are unobservable and/or unavailable. This paper is a typical and successful application of proxy measurement strategy. In this particular application, wearable IMU (Inertia Measurement Unit) sensors were used to measure the accelerations at different body levels. The acceleration signals were used as the p...
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Fine tuning scan time for improving preclinical assessment of bone tissue

  MultiSim’s researchers are trying to find ways to reduce and refine animal testing in pre-clinical trials by using computer models and medical imaging.  One application of these approaches is to study the effect of skeletal diseases such as osteoporosis and its treatments. At the University of Sheffield, high-resolution scans can be performed on mice to measure...
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Micro Finite Element models of the vertebral body: Validation of local displacement predictions

Computational models can be used to estimate the mechanical properties of bones under certain loading conditions. However, even if they are based on high-resolution micro-computed tomography (microCT) scans which provide information about the bone density and micro architecture, they need to be validated against accurate and well controlled experiments in the laboratory. In ...
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Journal of Biomechanics: Accuracy of synchrotron based digital volume correlation for bone tissue

MultiSim's Dr Enrico Dall'Ara  talks about his paper on the accuracy of synchrotron-based digital volume correlation for bone tissue. His research was featured on the homepage of the Journal of Biomechanics edition published in July 2017. Understanding bone mechanics at different hierarchical levels is fundamental to improve preclinical and clinical assessments of bone stren...
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Multiscale modelling methods in biomechanics

Multisim Again
  Dr Pinaki Bhattacharya talks about his research on the catergorisation for multiscale modelling in biomechanics. Multiscale modelling in biomechanics is a relatively new research domain. It has potential applications in preventing and developing treatments for a wide variety of diseases, however, because of this wide-ranging applicability, multiscale models that ...
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Research on Digital volume correlation (DVC)

Strain uncertainties from two digital volume correlation approaches in prophylactically augmented vertebrae A newly developed technique called digital volume correlation (DVC) can be used to access the internal deformation of heterogeneous materials and structures. DVC has been exploited over the past decade to measure complex deformation fields within biological tissues, suc...
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