A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint

Flow diagram illustrating the methods to extract the trabecular bone cortical bone volumes for morphometric analysis. Osteoarthritis affects the properties of the joints, changing its shape and mechanical response, and inducing pain to the patient. However, little is known about how these properties are related to the function of the joint, which is fundamental to optimis...
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Effect of size and location of simulated lytic lesions on the structural properties of human vertebral bodies, a micro-finite element study

Graphical Abstract The study of the risk of fractures in cancer patients with spine metastases is important to improve the quality of life of patients. Currently, the risk of fracture in these patients is evaluated using clinical scoring systems that account for information about the location of the cancer, the pain, and other qualitative factors. While this approac...
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An extended discrete element method for the estimation of contact pressure at the ankle joint during stance phase

Pressure distribution at the instant of maximum loading (78% of the stance). EDEM is on the left, DEM on the right. Abnormalities in the ankle contact pressure are related to the onset of osteoarthritis. In vivo measurements are not possible with currently available techniques, so computational methods are often used instead. The discrete element method (DEM) is a computa...
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Heterogeneity in the mechanical properties of integrins determines mechanotransduction dynamics in bone osteoblasts

Aban Shuaib, Daniyal Motan, Pinaki Bhattacharya, Alex Mcnabb, Timothy M. Skerry & Damien Lacroix We know that the effect on the skeleton of brief periods of exercise persists for over 24 hours – effectively bone remembers what loads it has experienced and uses that information to adapt its structure.  This tunes the skeleton to become strong enough to support habitual ...
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The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia: A comparison between two mouse strains

A thorough assessment of any prospective animal model of human disease is necessary before the substantial investment of resources into a preclinical study of potential therapies. Oestrogen-deficiency and related bone loss following ovariectomy is a common animal model of osteoporosis. In this study we quantified the effects of ovariectomy on the tibia bone morphometric, densi...
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Finite Element Modelling of the Developing Infant Femur Using Paired CT and MRI Scans

Finite Element models of infant femur (left– 4 months; right– 7 months) Through the MultiSim project in Sheffield, we have pioneered modelling technologies to investigate very young children’s bone using personalised computer models based on CT and MRI scans. This work is the first of its kind to combine information obtained from paired CT/MRI data in order to create deta...
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Biomechanical assessment of vertebrae with lytic metastases with subject-specific finite element models

The assessment of risk of vertebral fracture in patients with lytic metastases is challenging, due to the complexity in understanding their impact on the vertebral strength. Currently surgeons have to decide whether to fix the spine with implants or not, just based on their experience and on qualitative scoring systems such as the Spinal Instability Neoplastic Score (SINS...
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Linking Joint Impairment and Gait Biomechanics in Patients with Juvenile Idiopathic Arthritis

Radar plot visualisation of the joint contact force and joint power parameters normalised using robust z score
Radar plot visualisation of the joint contact force and joint power parameters normalised using robust z score. * = bilateral group significantly different from mono-lateral; † = bilateral group significantly different from control. This study, carried out as part of the MD-PAEDIGREE project, combines medical resonance images (MRI) and motion capture analysis to produce perso...
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Effect of cell sample size in atomic force microscopy nanoindentation

Graphical Abstract, showing cells, atomic force microscopy and the effect of sample size on the coefficient of variance of the Young's modulus of the cells Cells in the human body can be classified in many different ways. One of these is looking at their mechanical properties, and therefore at how stiff or soft they are. This characteristic has been shown to correlate to d...
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Pre-operative Prediction of Soft Tissue Balancing in Knee Arthoplasty

The definition of the body joints: ball socket (hip) and hinge (knee and ankle) A 2011 survey made over 18 developed high income countries reported that over 1.3 million total knee replacements are performed every year world-wide.  Since then these number have increased, because of the ageing of the population.  While only a few percent of the patients experience...
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