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The NC3Rs CRACK IT Challenges

Thursday, 7 September, 2017

The NC3Rs CRACK IT Challenges launch event to showcase the 2017 Challenges will take place on 7 September in central London.

The Challenges


  • Challenge 26: “DARTpaths”: Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects (Two Phase Challenge Sponsored by Shell and Syngenta).
  • Challenge 27“DoCE (Dosing for Controlled Exposure)”: Dosing strategies for characterising in vitro dose-responses with increased relevance for in vivo extrapolation. (Two Phase Challenge Sponsored by Unilever and Shell).
  • Challenge 28“RespiraTox”: In silico model for predicting human respiratory irritation. (Single Phase Challenge Sponsored by Shell).


Expertise needed to solve these Challenges includes, but is not limited to: Mathematical modelling, Data handling, In vitrobiology, Chemistry, (Bio/chemo-) informatics, Toxicology, QSAR development and validation, Statistics.

The Challenge briefs describing the Challenges, deliverables, in-kind contributions from the Sponsors and budgets is available now on the CRACK IT website.


  • Each of the Two Phase Challenges offers up to £1 million funding and a research contract for up to three years.
  • The Single Phase Challenge offers up to £100k funding and a research contract for up to one year.

Launch event

To find out more about the Challenges, meet the Sponsors and potential collaborators, and find out what makes a good application, you should attend the CRACK IT Challenges 2017 launch event on 7 September in central London. The launch event is free to attend but registration is essential.

To register, please download and complete the registration form on the CRACK IT website. The deadline for registration is 1 September 2017.

The competition

CRACK IT Challenges is a research competition to solve scientific and business problems identified by the bioscience sector. The Challenges are designed to reduce the reliance on animal models and/or improve animal welfare and lead to the development of marketable products. The CRACK IT Two Phase Challenges competition is run using the SBRI process which is supported by Innovate UK and Challenges are sponsored by companies who provide in-kind contributions such as data, validation and expertise.

Please contact if you would like to discuss this further.


Thursday, 7 September, 2017
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