Linking Joint Impairment and Gait Biomechanics in Patients with Juvenile Idiopathic Arthritis

Radar plot visualisation of the joint contact force and joint power parameters normalised using robust z score.
* = bilateral group significantly different from mono-lateral;
† = bilateral group significantly different from control.

This study, carried out as part of the MD-PAEDIGREE project, combines medical resonance images (MRI) and motion capture analysis to produce personalised musculoskeletal models employed in the investigation of joint impairment in children Juvenile Idiopathic Arthritis (JIA). Currently, the assessment of JIA mostly relies on the quantification of the local inflammation and damage in the joint region using static images. Linking these observations to a more dynamic information about the joint functional biomechanics might better predict the disease progression and support the treatment planning. In this study, joint kinetic parameters, such as joint powers and contact forces, were investigated and correlated to joint impairment, assessed with MRI-based evaluation. A moderate to strong correlation was observed between the impairment of one limb and the loading on the opposite limb, suggesting risky compensatory strategies being adopted, especially at the knee level.

Montefiori, E., Modenese, L., Di Marco, R., Magi-Manzoni, S., Malattia, C., Petrarca, M., Ronchetti, A., Tanturri de Horatio, L., van Dijkhuizen, P., Wang, A., Wesarg, S., Viceconti, M., Mazzà, C. for the MD-PAEDIGREE Consortium (2019), “Linking joint impairments and gait biomechanics in patients with Juvenile Idiopathic Arthritis”, Annals of Biomedical Engineering, URL: