MRI-based anatomical characterisation of lower-limb muscles in older women

Linear regression between muscle volume and anthropometric parameters
Linear regression between muscle volume and anthropometric parameters

The ability of muscles to produce force depends, among others, on their anatomical features and it is altered by ageing-associated weakening. This MRI-based study quantified for the first time anatomical asymmetry of lower-limb muscles in older women by characterising muscle volume, length, and physiological cross-sectional area (PCSA) and their variability, between body sides and between individuals. Results suggest that symmetry should not be assumed in older women and heavily question the validity of a generic-scaled approach when modelling the musculoskeletal system in older populations. The unique dataset of muscle segmentation made available with this paper could support the development of alternative population-based scaling approaches, together with that of automatic tools for muscle segmentation.

Montefiori, E., Kalkman, B. M., Henson, W. H., Paggiosi, M. A., McCloskey, E. V., Mazzà, C. (2020), “MRI-based anatomical characterisation of lower-limb muscles in older woman”, PLoS ONE, URL: https://doi.org/10.1371/journal.pone.0242973

Dataset: https://doi.org/10.15131/shef.data.9934055.v1