PTH(1–34) treatment and/or mechanical loading have different osteogenic effects on the trabecular and cortical bone in the ovariectomized C57BL/6 mouse

Figure showing increased apposition of bone (in red) when combining treatment (ML+PTH and ML+PTHalt), particularly in the midshaft (top row) and posterior and laterally where strains are highest under compressive load
Figure showing increased apposition of bone (in red) when combining treatment (ML+PTH and ML+PTHalt), particularly in the midshaft (top row) and posterior and laterally where strains are highest under compressive load

This study quantified the individual and combined longitudinal effects of PTH(1–34) and loading on the bone morphometric and densitometric properties in ovariectomised mice. Ovariectomised C57BL/6 mice were treated either with injections of PTH(1–34); compressive loading of the right tibia; both interventions concurrently; or both interventions on alternating weeks. Right tibiae were longitudinally imaged six times over 10 weeks using high-resolution microCT and the properties of the bone were quantified in 40 different regions along the limb length. The study showed that combined treatment had increased, albeit highly region-dependent, benefits to cortical bone that were largest in midshaft regions subjected to higher strains under compressive loads. Whereas combined treatment may limit benefits of loading on the trabecular bone.

Roberts, B.C., Arredondo Carrera, H.M., Zanjani-pour, S., Boudiffa, M., Wang, N., Gartland, A., Dall’Ara, E. (2020), “PTH(1–34) treatment and/or mechanical loading have different osteogenic effects on the trabecular and cortical bone in the ovariectomized C57BL/6 mouse”. Scientific Reports, 10, 8889.

URL: https://doi.org/10.1038/s41598-020-65921-1