The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia: A comparison between two mouse strains

A thorough assessment of any prospective animal model of human disease is necessary before the substantial investment of resources into a preclinical study of potential therapies. Oestrogen-deficiency and related bone loss following ovariectomy is a common animal model of osteoporosis. In this study we quantified the effects of ovariectomy on the tibia bone morphometric, densi...
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