Fine tuning scan time for improving preclinical assessment of bone tissue

  MultiSim’s researchers are trying to find ways to reduce and refine animal testing in pre-clinical trials by using computer models and medical imaging.  One application of these approaches is to study the effect of skeletal diseases such as osteoporosis and its treatments. At the University of Sheffield, high-resolution scans can be performed on mice to measure...
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Preclinical assessment of bone health

Dr. Enrico Dall'Ara  presented a seminar on Preclinical assessment of bone health with longitudinal imaging and finite element modelling at INSERM institute, Lyon, France. His session was hosted by Prof Philippe Clezardin and Dr Helene Follet. Dr Dall'Ara joined the University of Sheffield in 2013 in the Department of Mechanical Engineering. His research focuses on a better ...
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Collaboration with NC3Rs to reduce animal testing

Murine-embryo-stained-for-bone-and-cartilage
University of Sheffield's researchers are trying to find ways to reduce animal testing in preclinical trials by using computer models and medical imaging. One application of this technology, also known as in silico methods, is to study the effect of skeletal diseases such as osteoporosis and its treatments.Using in silico methods, researchers conducted a longitudinal study o...
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Sheffield: Alternatives to Research Requiring Rodents

The Sheffield event was attended by Dr Kasia Makowska, NC3Rs Press and Communications Officer: The event took place in a microbrewery, getting some curious looks from the beer-tasting tours. Dr Enrico Dall’Arra a researcher on the MultiSim project spoke about using a computer model, or a ‘digital mouse’, to better understand the mechanisms behind bone-related diseases. H...
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Dr Enrico Dall’Ara

Dr Dall'Ara is the leader of Work Package 7 - Animal Study, his main research interests are related to the characterisation of mechanical properties of biological tissues (in particular bone) at different length scales by using experimental, imaging and modelling approaches. The final goal of his research is the development of validation and calibration studies for CT-based...
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