Development of subject specific finite element models of the mouse knee joint for preclinical applications

Finite Element Models of the Knee Joint with increasing complexity
Osteoarthritis affects the properties of the joints, changing its shape and mechanical response, and inducing pain to the patient. Mouse models are commonly used to identify the effect of mechanical instability of the joint on its structure and to optimise treatments for reducing the joint degeneration. Computational models can be used to better understand the effect of the de...

Effect of size and location of simulated lytic lesions on the structural properties of human vertebral bodies, a micro-finite element study

Graphical Abstract The study of the risk of fractures in cancer patients with spine metastases is important to improve the quality of life of patients. Currently, the risk of fracture in these patients is evaluated using clinical scoring systems that account for information about the location of the cancer, the pain, and other qualitative factors. While this approac...