The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia: A comparison between two mouse strains

A thorough assessment of any prospective animal model of human disease is necessary before the substantial investment of resources into a preclinical study of potential therapies. Oestrogen-deficiency and related bone loss following ovariectomy is a common animal model of osteoporosis. In this study we quantified the effects of ovariectomy on the tibia bone morphometric, densi...
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Insigneo Team Visit Diamond Light Source

Beamtime on the Diamond Manchester Imaging Beamline (I13-2) was awarded to Dr Enrico Dall’Ara and Dr Bryant Roberts for proposal No: MG21628 “Assessing the individual and combined effects of parathyroid hormone (1-34) and mechanical loading on the micro- and nano-structural properties of murine cortical bone”. This study was partially funded by EPSRC MultiSim Grant: EP/K03877X...
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Variability in strain distribution in the mice tibia loading model: A preliminary study using digital volume correlation

  The study of bone remodeling, how bone tissue changes over time due to the activity of bone cells, is fundamental for the better understanding of musculoskeletal diseases and to design new treatments. Bone adapts to external loading and exercise can be used to stimulate the formation of new tissue in order to strengthen the bones.  Animal studies on small roden...
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