Bone remodelling in the mouse tibia is spatio-temporally modulated by oestrogen deficiency and external mechanical loading: A combined in vivo/in silico study

Graphical Abstract Understanding how bone formation and resorption are affected by several repeated periods of mechanical stimuli is important for developing personalised treatment plans for osteoporosis. In this study, the load-induced bone changes after the first and second week of mechanical loading was quantified for the first time in an animal model of osteoporosis. Co...
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Development of subject specific finite element models of the mouse knee joint for preclinical applications

Finite Element Models of the Knee Joint with increasing complexity
Osteoarthritis affects the properties of the joints, changing its shape and mechanical response, and inducing pain to the patient. Mouse models are commonly used to identify the effect of mechanical instability of the joint on its structure and to optimise treatments for reducing the joint degeneration. Computational models can be used to better understand the effect of the de...
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CLEAR IDEAS Workshop: Beyond Academia

Join MultiSim2 and explore how to take your research beyond academia, to the clinic, the industry and the public. Dr Kamal Birdi will be facilitating a creative thinking CLEAR IDEAS workshop to address these topics. Register.
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Heterogeneity in the mechanical properties of integrins determines mechanotransduction dynamics in bone osteoblasts

Aban Shuaib, Daniyal Motan, Pinaki Bhattacharya, Alex Mcnabb, Timothy M. Skerry & Damien Lacroix We know that the effect on the skeleton of brief periods of exercise persists for over 24 hours – effectively bone remembers what loads it has experienced and uses that information to adapt its structure.  This tunes the skeleton to become strong enough to support habitual ...
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EPSRC Engineering Research for Grand Challenges

MultiSim Stand at EPSRC Engineering Research for Grand Challenges, before the rushVisitors at MultiSim's stand at EPSRC Engineering Research for Grand ChallengeMultiSim Stand at EPSRC Engineering Research for Grand ChallengesMultiSim2 Team at Engineering Research for Grand Challenges Event (Left to Right) Erica Montefiori, Claudia Mazzà and Vee San Cheong Members of the Mul...
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MultiSim2 Launch

MultiSim2 Team and SAB
MultiSim2 Project Team and Scientific Advisory Board (SAB) Left to Right:Dr Joel Mitchelson, Codamotion (SAB),Dr Richard Mead, Neuroscience, University of Sheffield (SAB),Dr Bryant Roberts, Oncology and Metabolism (Researcher),Prof Claudia Mazzà, Mechanical Engineering (Principal Investigator) ,Dr Xinshan Li, Mechanical Engineering (Co-Investigator),Dr Enrico Dall'ara, Oncol...
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Modelathon 2020: Optimisation of interventions for osteoarthritic patients with multi-scale modelling

Monday, 13th, 10:00 to Thursday 16th, 13:00 January 2020 The Diamond, University of Sheffield Read how this event went. Day 1 Symposium: Experimental and computational approaches to optimise the treatment of osteoarthritis Day 2-4 Challenges: Optimisation of interventions for osteoarthritic patients with multi-scale modelling Our four-day E...
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1st EPSRC MultiSim Interdisciplinary Workshop on Multiscale Modelling

29th March 2019, ICOSS, University of Sheffield Participants networking and comparing approaches and challenges of using multiscale modelling in their disciplines On Friday, 29th March, a bright sunny Spring day in Sheffield, researchers from across disciplines in science and engineering with an interest in multiscale modelling gathered at the ICOSS Conference Centre. Th...
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MultiSim2 Awarded

Second phase of funding to expand research into modelling the human musculoskeletal system to tackle a broader range of ageing related and neurodegenerative conditions University of Sheffield research into modelling of human musculoskeletal system to assist the assessment, diagnosis and treatment options for individual patients has received a second phase funding via th...
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