Heterogeneous strain distribution in the subchondral bone of osteoarthritic femoral heads measured with digital volume correlation

Osteoarthritis affects the properties of the joints, changing its shape and mechanical response, and inducing pain to the patient. We still do not know how the complex structure of osteoarthritic bone deforms under load, due to the challenging experimental approaches required to evaluate the internal deformation in bone specimens. The goal of this study was to develop a method...
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Development of subject specific finite element models of the mouse knee joint for preclinical applications

Finite Element Models of the Knee Joint with increasing complexity
Osteoarthritis affects the properties of the joints, changing its shape and mechanical response, and inducing pain to the patient. Mouse models are commonly used to identify the effect of mechanical instability of the joint on its structure and to optimise treatments for reducing the joint degeneration. Computational models can be used to better understand the effect of the de...
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A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint

Flow diagram illustrating the methods to extract the trabecular bone cortical bone volumes for morphometric analysis. Osteoarthritis affects the properties of the joints, changing its shape and mechanical response, and inducing pain to the patient. However, little is known about how these properties are related to the function of the joint, which is fundamental to optimis...
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Researchers successfully tackle a multiscale Osteoarthritic knee challenge – Modelathon 2020

Modelathon Participants and Supporters The MultiSim, OATech+ Modelathon 2020 took place 13 – 16 January 2020 at the Diamond Building, Sheffield and aimed to provide an opportunity to discuss, network, and practise multi-scale research modelling skills through a hackathon competition with industry software and hands-on support from modelling experts. Modelathon 2020 was atte...
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Modelathon 2020: Optimisation of interventions for osteoarthritic patients with multi-scale modelling

Monday, 13th, 10:00 to Thursday 16th, 13:00 January 2020 The Diamond, University of Sheffield Read how this event went. Day 1 Symposium: Experimental and computational approaches to optimise the treatment of osteoarthritis Day 2-4 Challenges: Optimisation of interventions for osteoarthritic patients with multi-scale modelling Our four-day E...
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