MultiSim, Author at MultiSim

MultiSim2 goes ‘Beyond Academia’ with a CLEAR IDEAS Workshop

Posted on November 14, 2019November 15, 2019 by MultiSim

Kamal Birdi, warms participants by looking at chindōgu, weird Japanese inventions On Wednesday, 23rd October, our MultiSim2 project hosted a Clear Ideas workshop: Beyond Academia. The workshop was attended by the MultiSim2 team and Insigneo Associate Members from the IMSB (Integrated Musculo-Skeletal Biomechanics) group explored how to take their research Beyond Acad...

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Heterogeneity in the mechanical properties of integrins determines mechanotransduction dynamics in bone osteoblasts

Posted on September 27, 2019September 27, 2019 by MultiSim

Aban Shuaib, Daniyal Motan, Pinaki Bhattacharya, Alex Mcnabb, Timothy M. Skerry & Damien Lacroix We know that the effect on the skeleton of brief periods of exercise persists for over 24 hours – effectively bone remembers what loads it has experienced and uses that information to adapt its structure. This tunes the skeleton to become strong enough to support habitual ...

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EPSRC Engineering Research for Grand Challenges

Posted on September 18, 2019September 18, 2019 by MultiSim

MultiSim Stand at EPSRC Engineering Research for Grand Challenges, before the rushVisitors at MultiSim's stand at EPSRC Engineering Research for Grand ChallengeMultiSim Stand at EPSRC Engineering Research for Grand ChallengesMultiSim2 Team at Engineering Research for Grand Challenges Event (Left to Right) Erica Montefiori, Claudia Mazzà and Vee San Cheong Members of the Mul...

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MultiSim2 Launch

Posted on September 16, 2019September 16, 2019 by MultiSim

MultiSim2 Project Team and Scientific Advisory Board (SAB) Left to Right:Dr Joel Mitchelson, Codamotion (SAB),Dr Richard Mead, Neuroscience, University of Sheffield (SAB),Dr Bryant Roberts, Oncology and Metabolism (Researcher),Prof Claudia Mazzà, Mechanical Engineering (Principal Investigator) ,Dr Xinshan Li, Mechanical Engineering (Co-Investigator),Dr Enrico Dall'ara, Oncol...

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Modelathon 2020: Optimisation of interventions for osteoarthritic patients with multi-scale modelling

Posted on August 9, 2019December 4, 2019 by MultiSim

Monday, 13th, 10:00 to Thursday 16th, 13:00 January 2020 The Diamond, University of Sheffield Day 1 Symposium: Experimental and computational approaches to optimise the treatment of osteoarthritis Day 2-4 Challenges: Optimisation of interventions for osteoarthritic patients with multi-scale modelling Agenda coming soon ... Our four-day EPSRC fu...

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The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia: A comparison between two mouse strains

Posted on August 8, 2019August 8, 2019 by MultiSim

A thorough assessment of any prospective animal model of human disease is necessary before the substantial investment of resources into a preclinical study of potential therapies. Oestrogen-deficiency and related bone loss following ovariectomy is a common animal model of osteoporosis. In this study we quantified the effects of ovariectomy on the tibia bone morphometric, densi...

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Finite Element Modelling of the Developing Infant Femur Using Paired CT and MRI Scans

Posted on August 6, 2019August 6, 2019 by MultiSim

Finite Element models of infant femur (left– 4 months; right– 7 months) Through the MultiSim project in Sheffield, we have pioneered modelling technologies to investigate very young children’s bone using personalised computer models based on CT and MRI scans. This work is the first of its kind to combine information obtained from paired CT/MRI data in order to create deta...

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Biomechanical assessment of vertebrae with lytic metastases with subject-specific finite element models

Posted on July 12, 2019July 12, 2019 by MultiSim

The assessment of risk of vertebral fracture in patients with lytic metastases is challenging, due to the complexity in understanding their impact on the vertebral strength. Currently surgeons have to decide whether to fix the spine with implants or not, just based on their experience and on qualitative scoring systems such as the Spinal Instability Neoplastic Score (SINS...

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Test

Posted on July 11, 2019July 11, 2019 by MultiSim

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Linking Joint Impairment and Gait Biomechanics in Patients with Juvenile Idiopathic Arthritis

Posted on May 24, 2019May 24, 2019 by MultiSim

Radar plot visualisation of the joint contact force and joint power parameters normalised using robust z score. * = bilateral group signiﬁcantly different from mono-lateral; † = bilateral group signiﬁcantly different from control. This study, carried out as part of the MD-PAEDIGREE project, combines medical resonance images (MRI) and motion capture analysis to produce perso...

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