Heterogeneity in the mechanical properties of integrins determines mechanotransduction dynamics in bone osteoblasts

Aban Shuaib, Daniyal Motan, Pinaki Bhattacharya, Alex Mcnabb, Timothy M. Skerry & Damien Lacroix We know that the effect on the skeleton of brief periods of exercise persists for over 24 hours – effectively bone remembers what loads it has experienced and uses that information to adapt its structure.  This tunes the skeleton to become strong enough to support habitual ...
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EPSRC Engineering Research for Grand Challenges

MultiSim Stand at EPSRC Engineering Research for Grand Challenges, before the rushVisitors at MultiSim's stand at EPSRC Engineering Research for Grand ChallengeMultiSim Stand at EPSRC Engineering Research for Grand ChallengesMultiSim2 Team at Engineering Research for Grand Challenges Event (Left to Right) Erica Montefiori, Claudia Mazzà and Vee San Cheong Members of the Mul...
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MultiSim2 Launch

MultiSim2 Team and SAB
MultiSim2 Project Team and Scientific Advisory Board (SAB) Left to Right:Dr Joel Mitchelson, Codamotion (SAB),Dr Richard Mead, Neuroscience, University of Sheffield (SAB),Dr Bryant Roberts, Oncology and Metabolism (Researcher),Prof Claudia Mazzà, Mechanical Engineering (Principal Investigator) ,Dr Xinshan Li, Mechanical Engineering (Co-Investigator),Dr Enrico Dall'ara, Oncol...
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Modelathon 2020: Optimisation of interventions for osteoarthritic patients with multi-scale modelling

Monday, 13th, 10:00 to Thursday 16th, 13:00 January 2020 The Diamond, University of Sheffield Day 1 Symposium: Experimental and computational approaches to optimise the treatment of osteoarthritis Day 2-4 Challenges: Optimisation of interventions for osteoarthritic patients with multi-scale modelling Agenda coming soon ... Our four-day EPSRC fu...
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The longitudinal effects of ovariectomy on the morphometric, densitometric and mechanical properties in the murine tibia: A comparison between two mouse strains

A thorough assessment of any prospective animal model of human disease is necessary before the substantial investment of resources into a preclinical study of potential therapies. Oestrogen-deficiency and related bone loss following ovariectomy is a common animal model of osteoporosis. In this study we quantified the effects of ovariectomy on the tibia bone morphometric, densi...
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Finite Element Modelling of the Developing Infant Femur Using Paired CT and MRI Scans

Finite Element models of infant femur (left– 4 months; right– 7 months) Through the MultiSim project in Sheffield, we have pioneered modelling technologies to investigate very young children’s bone using personalised computer models based on CT and MRI scans. This work is the first of its kind to combine information obtained from paired CT/MRI data in order to create deta...
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Biomechanical assessment of vertebrae with lytic metastases with subject-specific finite element models

The assessment of risk of vertebral fracture in patients with lytic metastases is challenging, due to the complexity in understanding their impact on the vertebral strength. Currently surgeons have to decide whether to fix the spine with implants or not, just based on their experience and on qualitative scoring systems such as the Spinal Instability Neoplastic Score (SINS...
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Linking Joint Impairment and Gait Biomechanics in Patients with Juvenile Idiopathic Arthritis

Radar plot visualisation of the joint contact force and joint power parameters normalised using robust z score
Radar plot visualisation of the joint contact force and joint power parameters normalised using robust z score. * = bilateral group significantly different from mono-lateral; † = bilateral group significantly different from control. This study, carried out as part of the MD-PAEDIGREE project, combines medical resonance images (MRI) and motion capture analysis to produce perso...
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