Author: MultiSim

PTH(1–34) treatment and/or mechanical loading have different osteogenic effects on the trabecular and cortical bone in the ovariectomized C57BL/6 mouse

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Figure showing increased apposition of bone (in red) when combining treatment (ML+PTH and ML+PTHalt), particularly in the midshaft (top row) and posterior and laterally where strains are highest under compressive load This study quantified the individual and combined longitudinal effects of PTH(1–34) and loading on the bone morphometric and densitometric properties in ovari...
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A new approach to comprehensively evaluate the morphological properties of the human femoral head: example of application to osteoarthritic joint

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Flow diagram illustrating the methods to extract the trabecular bone cortical bone volumes for morphometric analysis. Osteoarthritis affects the properties of the joints, changing its shape and mechanical response, and inducing pain to the patient. However, little is known about how these properties are related to the function of the joint, which is fundamental to optimis...
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Researchers successfully tackle a multiscale Osteoarthritic knee challenge – Modelathon 2020

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Modelathon Participants and Supporters The MultiSim, OATech+ Modelathon 2020 took place 13 – 16 January 2020 at the Diamond Building, Sheffield and aimed to provide an opportunity to discuss, network, and practise multi-scale research modelling skills through a hackathon competition with industry software and hands-on support from modelling experts. Modelathon 2020 was atte...
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Effect of size and location of simulated lytic lesions on the structural properties of human vertebral bodies, a micro-finite element study

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Graphical Abstract The study of the risk of fractures in cancer patients with spine metastases is important to improve the quality of life of patients. Currently, the risk of fracture in these patients is evaluated using clinical scoring systems that account for information about the location of the cancer, the pain, and other qualitative factors. While this approac...
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An extended discrete element method for the estimation of contact pressure at the ankle joint during stance phase

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Pressure distribution at the instant of maximum loading (78% of the stance). EDEM is on the left, DEM on the right. Abnormalities in the ankle contact pressure are related to the onset of osteoarthritis. In vivo measurements are not possible with currently available techniques, so computational methods are often used instead. The discrete element method (DEM) is a computa...
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Heterogeneity in the mechanical properties of integrins determines mechanotransduction dynamics in bone osteoblasts

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Aban Shuaib, Daniyal Motan, Pinaki Bhattacharya, Alex Mcnabb, Timothy M. Skerry & Damien Lacroix We know that the effect on the skeleton of brief periods of exercise persists for over 24 hours – effectively bone remembers what loads it has experienced and uses that information to adapt its structure.  This tunes the skeleton to become strong enough to support habitual ...
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EPSRC Engineering Research for Grand Challenges

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MultiSim Stand at EPSRC Engineering Research for Grand Challenges, before the rushVisitors at MultiSim's stand at EPSRC Engineering Research for Grand ChallengeMultiSim Stand at EPSRC Engineering Research for Grand ChallengesMultiSim2 Team at Engineering Research for Grand Challenges Event (Left to Right) Erica Montefiori, Claudia Mazzà and Vee San Cheong Members of the Mul...
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MultiSim2 Launch

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MultiSim2 Team and SAB
MultiSim2 Project Team and Scientific Advisory Board (SAB) Left to Right:Dr Joel Mitchelson, Codamotion (SAB),Dr Richard Mead, Neuroscience, University of Sheffield (SAB),Dr Bryant Roberts, Oncology and Metabolism (Researcher),Prof Claudia Mazzà, Mechanical Engineering (Principal Investigator) ,Dr Xinshan Li, Mechanical Engineering (Co-Investigator),Dr Enrico Dall'ara, Oncol...
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