Effect of cell sample size in atomic force microscopy nanoindentation

Graphical Abstract, showing cells, atomic force microscopy and the effect of sample size on the coefficient of variance of the Young's modulus of the cells Cells in the human body can be classified in many different ways. One of these is looking at their mechanical properties, and therefore at how stiff or soft they are. This characteristic has been shown to correlate to d...
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Pre-operative Prediction of Soft Tissue Balancing in Knee Arthoplasty

The definition of the body joints: ball socket (hip) and hinge (knee and ankle) A 2011 survey made over 18 developed high income countries reported that over 1.3 million total knee replacements are performed every year world-wide.  Since then these number have increased, because of the ageing of the population.  While only a few percent of the patients experience...
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Prenatal growth map of the mouse knee joint by means of deformable registration technique

Methodological Pipeline Joint morphogenesis is the process of development of the joint that starts before the birth. It is important to study joint morphogenesis in order to understand how it is related to musculoskeletal diseases and to optimise related interventions. In several cases the interventions are tested on animal models and the mouse pre-natal model is typic...
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Poroelastic Modeling of Highly Hydrated Collagen Hydrogels: Experimental Results vs. Numerical Simulation with Custom and Commercial Finite Element Solvers

With the non-stop advances in computational methods and tools, researchers have a wide range of possibilities when it comes to choosing the most appropriate software for their work. In the field of biomechanics and biomaterials, one of the most used tools to predict and understand the behaviour of materials and devices is the finite element method, which allows for the ...
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Image-based Kinematic Ankle Models for Children affected by Juvenile Idiopathic Arthritis

Image-based Kinematic Ankle Model This study, carried on as part of the MD-PAEDIGREE project, presents an innovative application for kinematic ankle models, used here to understand possible disease-specific gait patterns in children affected by Juvenile Idiopathic Arthritis. The proposed methodology is based on the identification of the tibiotalar and subtalar axes from med...
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Variability in strain distribution in the mice tibia loading model: A preliminary study using digital volume correlation

  The study of bone remodeling, how bone tissue changes over time due to the activity of bone cells, is fundamental for the better understanding of musculoskeletal diseases and to design new treatments. Bone adapts to external loading and exercise can be used to stimulate the formation of new tissue in order to strengthen the bones.  Animal studies on small roden...
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Comparison of HR-pQCT- and microCT-based finite element models

The bedrock of developing robust Virtual Physiological Human is a robust and accurate digital transformation of existing medical procedures. The development of high-resolution imaging systems such as HR-pQCT (High Resolution Peripheral Quantitative Computed Tomography) has provided clinicians with a powerful tool for a 3D visualisation of patients’ internal bone structures (e...
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MultiSim’s research on the strength of children’s bones could help in the design of safer car seats

New research from MultiSim's academics based at Insigneo and Sheffield Children's hospitals looks into the strength of children's bones which could help in the design of safer car seats. The first study of its kind into infant bone strength in relation to age and weight using computer simulations The research from University of Sheffield, Sheffield Teaching Hospitals NH...
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Validation of calcaneus trabecular microstructure measurements by HR-pQCT

In the clinical management of osteoporosis, the most common bone disease that is associated with reduced bone strength and increased risk of broken bones (fractures), it is useful to be able to assess bone strength in individual patients.  Bone strength depends on the amount of bone (bone mass) as well as its structure.  The heel bone is a very accessible site for assessing bon...
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Precision of Digital Volume Correlation Approaches

University of Sheffield's researchers are improving the assessment of deformation in bone tissue using "Digital Volume Correlation" (DVC) approach that is considered a state-of-the-art image-processing technique.     This research aims to improve our knowledge about bone fracture mechanism. Particularly focusing on the bone fracture mechanism due to bone a...
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